AVERON NOTEBOOK TO DISCOVER ACTIONABLE CANCER VULNERABILITIES ENABLED BY NEOMORPH PROTEIN-PROTEIN INTERACTIONS

AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions

Summary: Genomic alterations, such as missense Fuse mutations, often lead to the activation of oncogenic pathways and cell transformation by rewiring protein-protein interaction (PPI) networks.Understanding how mutant-directed neomorph PPIs (neoPPIs) drive cancer is vital to developing new personalized clinical strategies.However, the experimental

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Extraction and Physicochemical Characterization of Chitin Derived from the Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae)

Fifteen years ago, at least one multimated female yellow-legged Asian hornet (Vespa velutina Lepeletier 1836) arrived in France, which gave rise to a pan-European invasion.In this study, the isolation and characterization of chitin (CHI) that was obtained from Vespa velutina (CHIVV) is described.In addition, an easy procedure is carried M Accesorie

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STATE LIABILITY FOR VIOLATION OF CONSTITUTIONAL RIGHTS AGAINST INDIGENOUS PEOPLE IN FREEDOM OF RELIGION AND BELIEF

The government is perceived as the main perpetrator on violations of freedom of religion and belief in Indonesia.As the state organizer, the government frequently issues discriminatory regulations and policies and tend to cause intolerance to minority religions and beliefs, particularly to indigenous peoples.While freedom of religion or belief is a

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A warped scalar portal to fermionic dark matter

Abstract We argue that extensions of the SM with a warped extra dimension, together with a new $${mathbb {Z}}_2$$ Z 2 -odd scalar singlet, provide a natural explanation not only for the hierarchy problem but also for the nature of fermion bulk masses and the observed dark matter relic abundance.In particular, the Kaluza-Klein excitations of the Fus

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